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What Are the Side Effects of Alpha Lipoic Acid?
Alpha lipoic acid side effects are usually mild: nausea, vomiting and indigestion, plus low blood sugar in some people. Rare serious problems have been reported at high doses. Synaptril lists alpha lipoic acid in its blend with no printed amount, so the label cannot tell you how much you get.
Written by the Synaptril label deskUpdated · 4 min read
What are the common side effects of alpha lipoic acid?
The common side effects of alpha lipoic acid are nausea, vomiting and indigestion. Memorial Sloan Kettering also lists low blood sugar (MSKCC About Herbs, Alpha-Lipoic Acid).
| Effect | How often it is reported |
|---|---|
| Nausea, vomiting, indigestion | Listed as side effects |
| Low blood sugar | Listed; watch with diabetes drugs |
| Insulin autoimmune syndrome | Rare: about 27 cases |
Are there rare or serious side effects?
Yes, but they are rare. Alpha lipoic acid may trigger insulin autoimmune syndrome, an autoimmune form of low blood sugar, in people with a genetic risk (MSKCC About Herbs, Alpha-Lipoic Acid).
The same source notes serious poisoning at high doses. Report any odd reaction to your clinician, and product problems to FDA (FDA, How to Report a Problem).
How much alpha lipoic acid is in a Synaptril capsule?
The label does not print it. Alpha lipoic acid is second in the 575 mg blend, and the magnesium math caps it at about 175 mg a capsule.
Studies ran from about 200 to 1,800 mg a day (Linus Pauling Institute, Lipoic Acid). A capsule sits well below the top of that range.
Tap a number to read that part of the panel.
- Serving
Serving size 1 capsule; 30 servings per container.
- Magnesium 80 mg
As magnesium glycinate from the proprietary blend: 19% of the Daily Value.
- 19% DV
The Daily Value for magnesium is 420 mg, so 80 mg is 19%.
- Proprietary blend, 575 mg
Six ingredients share 575 mg, listed most to least by weight.
- The six lines
Magnesium glycinate, alpha lipoic acid, butcher's broom root, L-carnitine, turmeric (95% curcuminoids), CoQ10.
- Other ingredients
The capsule shell and flow agents. No sweetener, caffeine or color is listed.
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See packsWhich Synaptril ingredients can upset the stomach?
Five of the six lines in Synaptril list a stomach or digestive effect in our sources, so one symptom can have more than one cause.
The blend hides each amount, which means a person cannot tell which line is behind a symptom.
| Line | Effect named |
|---|---|
| Magnesium glycinate | Diarrhea, nausea, cramping at high doses (NIH ODS, Magnesium) |
| Alpha lipoic acid | Nausea, vomiting, indigestion (MSKCC About Herbs, Alpha-Lipoic Acid) |
| L-carnitine | Nausea, cramps, diarrhea at about 3 g (NIH ODS, Carnitine) |
| Turmeric extract | Nausea, reflux, diarrhea (NCCIH, Turmeric) |
| Coenzyme Q10 | Digestive upset, insomnia (NCCIH, Coenzyme Q10) |
If a symptom starts with the first capsules and stays, stop and call a clinician.
Who should talk to a doctor first?
Anyone on insulin or diabetes medicine, anyone pregnant or nursing, and anyone under 18 should check first. The label bars the last two groups outright.
Keep taking prescribed medicine. See the full alpha lipoic acid profile and the Synaptril side effects page, or read about alpha lipoic acid and blood sugar.
FAQ01
Synaptril questions people ask
Does alpha lipoic acid cause rash or allergic reactions?
The sources we used do not list rash. They name nausea, vomiting, indigestion and low blood sugar. Any new rash after a supplement is worth a call to your clinician, and you can report it to FDA.
Is alpha lipoic acid in Synaptril the cause of stomach upset?
It could be one cause, but the label cannot tell. Other lines, such as magnesium and L-carnitine, can also upset the stomach. Stop and call a clinician if symptoms persist.
Can you take alpha lipoic acid every day?
The Synaptril label says one capsule daily. Our sources name no safe long-term limit for ALA, so ask your clinician if you plan to take it for many months.
Can alpha lipoic acid cause low blood sugar in people without diabetes?
Our sources list low blood sugar as a side effect without limiting it to people with diabetes, and they give no rate. Insulin autoimmune syndrome is a rare form of it. Call a clinician about any symptom that worries you.
Who wrote this02
Written and reviewed by
Pages built from the label, the sales page and linked NIH, FDA, CDC, FTC and peer-reviewed sources.
Last updated . Learn about our editorial standards and how we check reviews. This website is run by a U.S. retail partner of Synaptril, not by the manufacturer or the distributor. We make money when you buy through our order links.
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